Women who are positive for the BRCA1 gene are known to have poor DNA repair. These women may benefit from PARP inhibitors. BRCA1 is associated with aggressive and often lethal breast cancer as well as colon cancer.
Niacinamide, a B Vitamin, may help breast cancer and ovarian cancer patients. Recently another gene associated with poor DNA repair has been identified. This gene, RAD51D, is associated with increased risk for ovarian cancer. PARP Inhibitor drugs as well as Niacinamide may also be of value to these women.